Reviewed & updated August 23, 2026

What Is an STD?

Quick answer

An STD (sexually transmitted disease) is an infection passed primarily through vaginal, anal or oral sex and other intimate skin-to-skin contact. More than 30 pathogens — bacteria, viruses and parasites — cause STDs, including chlamydia, gonorrhea, syphilis, herpes, HIV, HPV and trichomoniasis. Most cause few or no symptoms at first, which is why testing matters.

The plain-English definition

An STD is a health condition you catch mainly through sexual contact. The germs involved live in semen, vaginal fluids, rectal fluids, blood, and on skin around the genitals, mouth and anus. When one of those germs moves between partners during sex — or through close intimate touch — it can establish an infection.

Doctors recognize more than 30 different sexually transmitted pathogens, according to the World Health Organization. Some are bacteria your antibiotics can eliminate completely (chlamydia, gonorrhea, syphilis). Some are viruses that stay in your body but are manageable (herpes, HIV) or preventable by vaccine (HPV, hepatitis B). And some are parasites or protozoa you can wash out entirely, like pubic lice ("crabs") and trichomoniasis.

Key distinction: technically, an infection means a germ has taken up residence; a disease means it's causing signs or illness. That's why modern medicine prefers "STI" — see our guide on STI vs STD.

The main types of STDs

STDs sort into four biological families:

Our ranked overview covers the most common STDs with case counts.

How STDs actually spread

The classic route is unprotected vaginal or anal sex. But transmission doesn't require intercourse: oral sex passes gonorrhea, syphilis, herpes and HPV effectively; deep kissing transmits HSV-1; genital skin-to-skin contact spreads herpes, HPV and pubic lice even with a condom on. A pregnant person can also pass syphilis, HIV, hepatitis B or herpes to their baby during pregnancy or delivery.

1 in 5US residents had an STI on any given day (CDC estimate)
26Mnew STIs occur in the US every year
>30pathogens spread mainly by sexual contact (WHO)
~50%of new US infections hit people aged 15–24

What STDs don't do: jump from toilet seats, hugs, handshakes, shared plates or swimming pools. See the science behind the toilet-seat myth.

What an STD looks and feels like

Here's the uncomfortable truth: most STDs announce themselves quietly or not at all. Chlamydia is symptom-free in roughly 70% of women and half of men. Herpes spends most of its life dormant. Early HIV mimics the flu. When symptoms do appear they typically include:

We break down every sign in detail in Signs of an STD and How Do You Know If You Have an STD?

Testing and treatment: the good news

Nearly everything on this page is detectable with simple tests — urine samples, quick swabs or a vial of blood. Results usually return within one to three days. Bacterial and parasitic STDs cure completely with short courses of medication; viral ones become chronic but respond well to suppressive therapy, and HIV treatment today drives the virus to undetectable levels.

If you're due for a check-up, compare every option — clinics, private labs, urgent care and home kits — in Where to Get Tested for STDs, then see how soon after exposure each test turns positive in our testing window chart.

Frequently asked questions

What does STD stand for?
STD stands for sexually transmitted disease — an infection acquired primarily through sexual contact. The newer equivalent term is STI (sexually transmitted infection).
Is there a difference between an STD and an STI?
Medically, an infection precedes a disease: STI describes having the germ, STD describes the resulting illness. In everyday use the terms are interchangeable, and doctors increasingly say STI to reduce stigma.
Can you have an STD without symptoms?
Yes — this is common. Around 70% of chlamydia cases in women, most HPV infections, and the majority of herpes and trichomoniasis cases produce no noticeable early symptoms. Regular testing is the only reliable detection method.
Are all STDs serious?
Untreated, several STDs cause serious harm — infertility, cancer, neurological damage or death. Caught early, almost all are either curable or highly manageable, which is why prompt testing matters more than worrying.
Can kissing give you an STD?
Deep kissing can transmit HSV-1 (cold sores), and mouth sores can pass syphilis in rare cases. HIV, chlamydia and gonorrhea are not meaningfully transmitted through kissing.
What's the single most common STD?
Among nationally reported US diseases, chlamydia ranks #1 (1.6 million cases in 2023). Counting unreported infections, HPV and herpes are far more widespread.

Sources & further reading